Stemness features in liver cancer
نویسندگان
چکیده
منابع مشابه
Reversing cancer stemness
lethality of malignant breast cancer in human patients. Although various targeted and non-targeted therapies can occasionally control the progress of breast cancer, a significant portion of patients develop resistance to chemotherapy and experience metastatic recurrence. The epithelial to mesenchymal transition (EMT), a key developmental program in embryogenesis, has been found to be closely in...
متن کاملCancer: The Future Features in Iran
Today, cancer is the main reason of the 12 % of mortality around the world. It is the second most important reason of death in the developed countries and the third most important one in the developing countries. The frequency of cancer cases in the developed countries is much higher than that of the developing countries, but statistics signify that the rate of cancer incidence is increasing fa...
متن کاملKnock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation.
CD44 is a widely known cancer stem cells marker in various cancers and validated to function in tumor growth, survival and tumor metastasis. In this study, we first established C3A-derived liver cancer stem cells by OSKM method [OCT4, SOX2, KLF4, and c-MYC], termed C3A-induced cancer stem cells (C3A-iCSCs) which acquired self-renewal and stemness abilities. Then we found CD44 was positive in C3...
متن کامل“De-coding” Stemness Pathways in Cancer
Submit Manuscript | http://medcraveonline.com Abbreviations: ncRNAs: Noncoding RNAs; miRs: MicroRNAs; lncRNAs: Long noncoding RNAs; RISC: RNA-Induced-SilencingComplex; mRNAs: Messenger RNAs; CLL: Chronic Lymphocytic Leukemia; RREB1: Ras-Responsive Element-Binding Protein 1; HK2: Hexokinase 2; AldoA: Aldolase A; GPD2: Glycerol-3-phosphate dehydrogenase-2; Xist: X Inactive Specific Transcript; XC...
متن کاملCisplatin induces stemness in ovarian cancer
The mainstay of treatment for ovarian cancer is platinum-based cytotoxic chemotherapy. However, therapeutic resistance and recurrence is a common eventuality for nearly all ovarian cancer patients, resulting in poor median survival. Recurrence is postulated to be driven by a population of self-renewing, therapeutically resistant cancer stem cells (CSCs). A current limitation in CSC studies is t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hepatoma Research
سال: 2018
ISSN: 2454-2520,2394-5079
DOI: 10.20517/2394-5079.2018.96